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Examples of Safe Dosing Adjustments After Missing Ozempic Scenario 1: 3-Day Delay Scheduled dose: Monday Missed dose noticed: Thursday Action: Take missed dose Thursday, continue next regular dose following Monday Scenario 2: 6-Day Delay Scheduled dose: Monday Missed dose noticed: Sunday Action: Skip missed dose, wait for next scheduled Monday dose For extended gaps in treatment (more than two weeks), patients should contact their healthcare provider about restarting treatment

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In Phase 2 clinical trials, 88.8% of participants successfully completed 48 weeks of treatment despite experiencing some side effects along the way

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(D) Liver citrate synthase activity, determined as described in Materials and Methods